Implications of Shallower Memory Controller Transaction Queues in Scalable Memory Systems

Scalable memory systems provide scalable bandwidth to the core growth demands in multicores and embedded systems processors. In these systems, as memory controllers (MCs) are scaled, memory traffic per MC is reduced, so transaction queues become shallower. As a consequence, there is an opportunity to explore transaction queue utilization and its impact on energy utilization. In this paper, we propose to evaluate the performance and energy-per-bit impact when reducing transaction queue sizes along with the MCs of these systems. Experimental results show that reducing 50 % on the number of entries, bandwidth and energy-per-bit levels are not affected, whilst reducing aggressively of about 90 %, bandwidth is similarly reduced while causing significantly higher energy-per-bit utilization

Insula-specific 1H magnetic resonance spectroscopy reactions in heavy smokers under acute nicotine withdrawal and after oral nicotine substitution

The aim of this study was to clarify whether addiction-specific neurometabolic reaction patterns occur in the insular cortex during acute nicotine withdrawal in tobacco smokers in comparison to nonsmokers. Fourteen male smokers and 10 male nonsmokers were included. Neurometabolites of the right and the left insular cortices were quantified by magnetic resonance spectroscopy (MRS) on a 3-Tesla scanner. Three separate MRS measurements were performed in each subject: among the smokers, the first measurement was done during normal smoking behavior, the second measurement during acute withdrawal (after 24 h of smoking abstinence), and the third shortly after administration of an oral nicotine substitute. Simultaneously, craving, withdrawal symptoms, and CO levels in exhaled air were determined during the three phases. The participants in the control group underwent the same MR protocol. In the smokers, during withdrawal, the insular cortex showed a significant increase in glutamine (Gln; p = 0.023) as well as a slight increase not reaching significance for glutamine/glutamate (Glx; p = 0.085) and a nonsignificant drop in myoinositol (mI; p = 0.381). These values tended to normalize after oral nicotine substitution treatment, even though differences were not significant: Gln (p = 0.225), Glx (p = 0.107) and mI (p = 0.810). Overall, the nonsmokers (control group) did not show any metabolic changes over all three phases (p > 0.05). In smokers, acute nicotine withdrawal produces a neurometabolic reaction pattern that is partly reversed by the administration of an oral nicotine substitute. The results are consistent with the expression of an addiction-specific neurometabolic shift in the brain and confirm the fact that the insular cortex seems to play a possible role in nicotine dependence